Preparation, fractionation, and characterization of solubilized elastin peptides and comparison of cellular response on fibroblasts and macrophages

This data collection contains research data underlying the results of a scientific research article. Below is a short explanation of the experiments and the content of the collection. Background: Elastin and its derivatives are considered promising biomaterials because of their biological functionality, distinctive natural crosslinking, and capacity to replicate the characteristics of native tissue. Solubilized elastin peptides preserve elastin’s bioactivity and are better suited for wound healing applications than their insoluble counterparts. Goal of the research: We evaluated the differences between various solubilized elastin preparations, with a specific emphasis on their production methods, physicochemical properties, and biological effects on human primary skin fibroblasts and macrophages. These comparisons were intended to enhance our understanding of how different solubilization approaches impact the resulting material's composition and functional behavior.