Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models

This data collection contains research data underlying the results of a scientific research article. Below is a short explanation of the experiments and the content of the collection. Background: Extensive full-thickness skin wounds typically result in significant scarring, which can lead to lasting complications and require prolonged medical care. Although autologous split-thickness skin grafts are the current standard in clinical practice, they often cause contractures, prominent scarring, and may necessitate further corrective surgeries. To overcome these limitations, there is a strong need for bioengineered skin substitutes that can support effective healing while minimizing associated complications. Goal of the research: We examined and directly compared the impact of two forms of chemically solubilized elastin - produced via acidic and alkaline hydrolysis - on wound healing. Novel collagen-elastin scaffolds were developed and thoroughly characterized, then tested on different fibroblast types, including normal dermal adult, eschar-derived, and fetal fibroblasts. Furthermore, we assessed the scaffolds' influence on tissue regeneration and scar formation in a rat model, offering the first direct comparison of these materials in vivo.