The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function

van Tuijl, J.

Vreeken, D.

Broeders, W.

Cossins, B.

van Emst, L.

Seidel, F.

Stienstra, R.

Li, Y.

A. B. Joosten , L.

G. Netea, M.

Hazebroek, E.

Kleemann, R.

J. Kiliaan, A.

Bekkering, S.

Riksen, N.P.

In this collection, you can find the following datasets from the BARICO study: (1) raw and normalized gene counts from a subset of 10 randomly selected obese patients undergoing Roux-and-Y gastric bypass surgery (BS) and 10 normal weight controls; (2) raw and normalized gene counts from monocytes stimulated with both subcutaneous (SAT) and visceral (VAT) adipose tissue at the pre-BS and post-BS time-point; (3) sample list containing the study participants IDs and stimulation conditions when applicable. The BARICO is an observational case-cohort study cohort study composed of twenty-seven patients with obesity (age 46.8 ± 6) who underwent BS in the period 2019-2020 and 20 normal weight subjects (age 43.4 ± 6). It aims to study the persistence of innate immune cell hyper-responsiveness following BS surgery and explore the potential contribution of adipose tissue in stimulation monocyte functions.